Trimix (Papaverine/Phentolamine /Alprostadil) 30/1/10mcg/ml


Tri-mix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.

While the components of Tri-mix are, on there own, indicated for a vast number of very different conditions (papaverine, phentolamine, PGE1 monographs), the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered the go-to treatment if conventional PDE5 inhibitors if a patient is not responsive to Viagra or Cialis.

Available on backorder



Indications: Tri-Mix is indicated in the treatment of erectile dysfunction in males. Tri-Mix contains three drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:

1.) Papaverine: A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the penis.
2.) Phentolamine: When injected into the penis, it induces an erection by relaxing and dilating the blood vessels of the penis, as well as by elevating cardiac output.
3.) Prostaglandin E1: A potent hormone-like substance that induces erection by relaxing the penis’s blood vessels and dilating cavernosal arteries–dilation of the cavernosal arteries is accompanied by increased arterial inflow velocity and increased venous outflow resistance allowing for more blood into the penis and less blood out.

Mechanism of Action: Though each of the pharmacological agents in Tri-mix act through separate mechanisms, each strives to elicit one or several of the responses that allow the induction of an erection: relaxing & dilating the vessels of the penis, icnreasing blood flow into the penis, and decreasing blood flow out.

Reasons not to take this medicine: Do not take this medicine with any of the following medications: hypersensitivity or allergy to any component of this formulation; conditions predisposing you to priapism (painful erection lasting 4 hours or more): sickle cell anemia, multiple myeloma or leukemia; anatomical deformation of the penis or with penile implants; direction by your physician that sexual activity is inadvisable or contraindicated.

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